Metabolomics analysis of post-traumatic stress disorder symptoms in World Trade Center responders

Autor: Pei-Fen Kuan, Xiaohua Yang, Roman Kotov, Sean Clouston, Evelyn Bromet, Benjamin J. Luft
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Translational Psychiatry, Vol 12, Iss 1, Pp 1-7 (2022)
Druh dokumentu: article
ISSN: 2158-3188
DOI: 10.1038/s41398-022-01940-y
Popis: Abstract Metabolomics has yielded promising insights into the pathophysiology of post-traumatic stress disorder (PTSD). The current study expands understanding of the systems-level effects of metabolites by using global metabolomics and complex lipid profiling in plasma samples from 124 World Trade Center responders (56 PTSD, 68 control) on 1628 metabolites. Differential metabolomics analysis identified hexosylceramide HCER(26:1) associated with PTSD at FDR
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