Gray Matter Abnormalities in Non-comorbid Medication-naive Patients with Major Depressive Disorder or Social Anxiety Disorder

Autor: Youjin Zhao, Lizhou Chen, Wenjing Zhang, Yuan Xiao, Chandan Shah, Hongru Zhu, Minlan Yuan, Huaiqiang Sun, Qiang Yue, Zhiyun Jia, Wei Zhang, Weihong Kuang, Qiyong Gong, Su Lui
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: EBioMedicine, Vol 21, Iss C, Pp 228-235 (2017)
Druh dokumentu: article
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2017.06.013
Popis: Background: An overlap of clinical symptoms between major depressive disorder (MDD) and social anxiety disorder (SAD) suggests that the two disorders exhibit similar brain mechanisms. However, few studies have directly compared the brain structures of the two disorders. The aim of this study was to assess the gray matter volume (GMV) and cortical thickness alterations between non-comorbid medication-naive MDD patients and SAD patients. Methods: High-resolution T1-weighted images were acquired from 37 non-comorbid MDD patients, 24 non-comorbid SAD patients and 41 healthy controls (HCs). Voxel-based morphometry analysis of the GMV (corrected with a false discovery rate of p
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