Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme
| Autor: | Steven Dajnowicz, Ryne C. Johnston, Jerry M. Parks, Matthew P. Blakeley, David A. Keen, Kevin L. Weiss, Oksana Gerlits, Andrey Kovalevsky, Timothy C. Mueser |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 59988460 |
| DOI: | 10.1038/s41467-017-01060-y |
| Popis: | Pyridoxal 5’-phosphate (PLP) is a ubiquitous co factor for diverse enzymes, among them aspartate aminotransferase. Here the authors use neutron crystallography, which allows the visualization of the positions of hydrogen atoms, and computation to characterize the catalytic mechanism of the enzyme. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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