Autor: |
K.-J. D. F. Lensen, R. Escudero-Sanchez, J. Cobo, R. Trebše, C. Gubavu, S. Tedeschi, J. M. Lomas, C. Arvieux, D. Rodriguez-Pardo, M. Fantoni, M. J. G. Pais, F. Jover, M. J. C. Salles, I. Sancho, M. F. Sampedro, A. Soriano, M. Wouthuyzen-Bakker |
Jazyk: |
angličtina |
Rok vydání: |
2021 |
Předmět: |
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Zdroj: |
Journal of Bone and Joint Infection, Vol 6, Pp 313-319 (2021) |
Druh dokumentu: |
article |
ISSN: |
2206-3552 |
DOI: |
10.5194/jbji-6-313-2021 |
Popis: |
Objectives: Patients with prosthetic joint infections (PJIs) not suitable for curative surgery may benefit from suppressive antibiotic therapy (SAT). However, the usefulness of SAT in cases with a draining sinus has never been investigated. Methods: A multicentre, retrospective observational cohort study was performed in which patients with a PJI and a sinus tract were eligible for inclusion if managed conservatively and if sufficient follow-up data were available (i.e. at least 2 years). SAT was defined as a period of > 6 months of oral antibiotic therapy. Results: SAT was initiated in 63 of 72 (87.5 %) included patients. Implant retention during follow-up was the same in patients receiving SAT vs. no SAT (79.4 % vs. 88.9 %; p=0.68). In total, 27 % of patients using SAT experienced side effects. In addition, the occurrence of prosthetic loosening in initially fixed implants, the need for surgical debridement, or the occurrence of bacteremia during follow-up could not be fully prevented with the use of SAT, which still occurred in 42 %, 6.3 %, and 3.2 % of cases, respectively. However, the sinus tract tended to close more often (42 % vs. 13 %; p=0.14), and a higher resolution of pain was observed (35 % vs. 14 %; p=0.22) in patients receiving SAT. Conclusions: SAT is not able to fully prevent complications in patients with a draining sinus. However, it may be beneficial in a subset of patients, particularly in those with pain or the hindrance of a draining sinus. A future prospective study, including a higher number of patients not receiving SAT, is needed. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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