Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay

Autor: Sophie Martin, Kevin C. Allan, Otis Pinkard, Thomas Sweet, Paul J. Tesar, Jeff Coller
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-32766-3
Popis: Mutations in tRNA processing factors can lead to myelin disorders. This study shows that differentiated oligodendrocytes, cells that make the myelin, are characterized by different tRNA modifications and mRNA decay compared to their precursor cells.
Databáze: Directory of Open Access Journals