PGC1 alpha coactivates ERG fusion to drive antioxidant target genes under metabolic stress

Autor: Aiindrila Dhara, Imlimaong Aier, Ankush Paladhi, Pritish Kumar Varadwaj, Sumit Kumar Hira, Nirmalya Sen
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03385-x
Popis: PGC1α acts as a co-activator of the ERG transcription factor during metabolic stress resulting in antioxidant functionsand inhibition of the PGC1α-ERG driven transcriptional program reduces prostate cancer growth by inducing ROS mediated apoptosis.
Databáze: Directory of Open Access Journals
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