Local treatment of breast cancer brain metastases
| Autor: | Ana Magličić, Paula Podolski, Nera Šarić, Majana Soče, Maja Baučić, Sanja Vušković, Tena Mlinarić-Koprivanac, Dora Šimović, Petra Đelalija, Ivan Zrilić, Martina Bašić-Koretić |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Libri Oncologici, Vol 50, Iss 2-3, Pp 126-130 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0300-8142 2584-3826 |
| DOI: | 10.20471/LO.2022.50.02-03.19 |
| Popis: | Breast cancer, along with lung cancer and melanoma, is one of the most common origins of central nervous system metastases. Due to improvement of systemic therapy options for primary disease and consequential prolonged survival, treatment of brain metastasis (BM) is presenting an evolving challenge. While new systemic therapy approaches for breast cancer brain metastasis are focusing on overcoming the blood brain and blood tumor barrier, as well as targeted therapies, local therapy remains the primary line of treatment. The decision of which local therapies to use, depends upon the number and volume of BM, their localization, patient’s clinical status, previously used treatments, status of extracranial disease and patient’s prognosis. In cases when an active approach, including surgery and/or radiotherapy, does not bring benefit to the patient’s quality of life or overall survival, best supportive care is recommended. |
| Databáze: | Directory of Open Access Journals |
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