N 6-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice

Autor: Xiangyu Wang, Yan Ding, Ran Li, Rujun Zhang, Xuejun Ge, Ruifang Gao, Miao Wang, Yubing Huang, Fang Zhang, Bin Zhao, Wang Liao, Jie Du
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-36865-7
Popis: N6-methyladenosine (m6A) methylation of RNA is a common type of RNA modification that regulates gene expression. Here, the authors report m6A methylation of serpin 2 A negatively regulates inflammation and reduces heart dysfunction in the setting of sepsis.
Databáze: Directory of Open Access Journals