| Autor: |
Bader Alshehri, Rajendran Vijayakumar, Subramanian Senthilkumar, Ahmed Ismail, Ahmed Abdel-Hadi, Ranjay K. Choudhary, Kamal S. Albenasy, Saeed Banawas, Mohammed A Alaidarous, Palanisamy Manikandan |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Saudi Journal of Biological Sciences, Vol 29, Iss 2, Pp 984-991 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1319-562X |
| DOI: |
10.1016/j.sjbs.2021.10.003 |
| Popis: |
Nitric oxide (NO) is one of the major signalling molecules in the mammalian body playing critical role in regulation of blood pressure, cardiovascular disease including stroke, immune activation, neuronal and cell communication. Moreover, hyper production of NO by the activity of nitric oxide synthase (NOS) involved in neuropathic pain, neurodegenerative disorders and stroke. Hence, the search on small molecules from the natural sources for the inhibition of NOS is desirable in therapeutic point of view. The elevated level of NO caused by NOS enzyme become a novel target in finding new inhibitors from natural sources as antistroke agents. The present study focuses on the molecular docking of quercetin and its analogues against NOS. The active site of the enzyme was docked with the ligand and pharmacological properties were analysed. From this result, we suggest the therapeutic property of quercetin and its analogues against NOS. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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