| Autor: |
Na Wu, Fan Yuan, Siran Yue, Fengyan Jiang, Decheng Ren, Liangjie Liu, Yan Bi, Zhenming Guo, Lei Ji, Ke Han, Xiao Yang, Mofan Feng, Kai Su, Fengping Yang, Xi Wu, Qing Lu, Xingwang Li, Ruirui Wang, Baocheng Liu, Shenglong Le, Yi Shi, Guang He |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Cell & Bioscience, Vol 11, Iss 1, Pp 1-14 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-3701 |
| DOI: |
10.1186/s13578-021-00701-6 |
| Popis: |
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is a disorder that extends from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which is effectively alleviated by lifestyle intervention. Nevertheless, DNA methylation mechanism underling the effect of environmental factors on NAFLD and NASH is still obscure. The aim of this study was to investigate the effect of exercise and diet intervention in NAFLD and NASH via DNA methylation of GAB2. Methods Methylation of genomic DNA in human NAFLD was quantified using Infinium Methylation EPIC BeadChip assay after exercise (Ex), low carbohydrate diet (LCD) and exercise plus low carbohydrate diet (ELCD) intervention. The output Idat files were processed using ChAMP package. False discovery rate on genome-wide analysis of DNA methylation (q |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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