Viral Dynamic Model of Antiretroviral Therapy Including the Integrase Inhibitor Raltegravir in Patients with HIV-1
| Autor: | Dimitra Bon, Christoph Stephan, Oliver Keppler, Eva Herrmann |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Biomath, Vol 1, Iss 1 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1314-684X 1314-7218 49428519 |
| DOI: | 10.11145/j.biomath.2012.09.251 |
| Popis: | Antiviral combination therapies consisting of reverse transcriptase inhibitors, protease inhibitors and an integrase inhibitor, have been developed to suppress HIV below the limit of detection. We introduce a mathematical model for the effect of different combination treatment regimens on the dynamics of HIV RNA and CD4 T-cell counts. We will especially focus on modelling the treatment effect of the integrase inhibitor-Raltegravir. The model consists of a system of ordinary differential equations and the parameters were chosen or estimated in order to agree with clinical data of a recent clinical trial. All the numerical simulations were calculated with Matlab. |
| Databáze: | Directory of Open Access Journals |
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