| Autor: |
Gurpreet Dhillon, MRCP, BSc, PhD, Shohreh Honarbakhsh, MRCP, PhD, BSC, Hakam Abbas, MSc, Peter Waddingham, MRCP, BSc, Adam S. Dennis, MRCP, BSc, Nikhil Ahluwalia, MRCP, BSc, Malcolm Finlay, PhD, Afzal Sohaib, PhD, Sophie Welch, PhD, Holly Daw, MSc, Simon Sporton, FRCP, MD, Anthony Chow, FRCP, MD, Mark J. Earley, FRCP, MD, Pier D. Lambiase, FHRS, PhD, Ross J. Hunter, FESC, FEHRA, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Heart Rhythm O2, Vol 4, Iss 10, Pp 609-617 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5018 |
| DOI: |
10.1016/j.hroo.2023.08.004 |
| Popis: |
Background: Mechanisms sustaining persistent atrial fibrillation (AF) remain unclear. Objectives: The study sought to evaluate both the clinical outcomes and response to ablation of potential drivers in patients with recurrent persistent AF recurrence following pulmonary vein isolation (PVI). Methods: A total of 100 patients with persistent AF of 1.5 revolutions or focal activations. Cycle lengths were measured pre- and postablation. The primary outcome was freedom from atrial arrhythmia off antiarrhythmic drugs at 1 year as per guidelines. Results: Of 37 patients recruited, 26 had recurrent AF and underwent ECGI-guided ablation of PDs. An average of 6.4 ± 2.7 PDs were targeted per patient. The mean ablation time targeting PDs was 15.5 ± 6.9 minutes. An ablation response occurred in 20 patients (AF termination in 6, cycle length prolongation ≥10% in 14). At 1 year, 14 (54%) of 26 patients were free from arrhythmia, and 12 (46%) of 26 were off antiarrhythmic drugs. Considering the 96 patients who completed follow-up out of the original cohort of 100 patients undergoing cryoablation in this staged strategy, freedom from arrhythmia at 1 year following the last procedure was 72 (75%) of 96, or 70 (73%) of 96 off antiarrhythmic drugs. Conclusions: In patients with recurrent AF despite PVI, ECGI-guided ablation caused an acute response in a majority with reasonable long-term outcomes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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