Autor: |
Amine Bouchlarhem, Leila Haddar, Oussama Lamzouri, Onci-Es-Saad, Siham Nasri, Narjisse Aichouni, Houssam Bkiyar, Yassine Mebrouk, Imane Skiker, Brahim Housni |
Jazyk: |
angličtina |
Rok vydání: |
2021 |
Předmět: |
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Zdroj: |
Radiology Case Reports, Vol 16, Iss 11, Pp 3602-3609 (2021) |
Druh dokumentu: |
article |
ISSN: |
1930-0433 |
DOI: |
10.1016/j.radcr.2021.08.030 |
Popis: |
Since the introduction of tyrosine kinase inhibitors as primary therapy for patients with chronic myeloid leukemia (CML), the prognosis of these patients has improved significantly, and the number of patients who progress to the blast phase has decreased considerably. We report the case of a 35 year-old CML patient in accelerated phase treated with nilotinib, who presents a severe COVID-19 infection requiring non-invasive ventilation, and who subsequently presents a multiple cranial nerve palsy revealing a blast crisis of his CML. Multiple cranial nerve palsy is a sign of neurological involvement of CML in its blast phase. The blast crisis represents a real challenge for the clinician, especially during COVID-19 infection. The treatment remains the association of a tyrosine kinase inhibitors with a chemotherapy protocol, as well as the administration of methotrexate and cytarabine by intrathecal and intravenous infusion in high doses. Despite the importance of the association of CML with COVID-19 infection, there is not yet enough data to know the true impact of this infection on the evolution of this hemopathy. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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