| Autor: |
Oscar Martínez-Alvarez, Rozenn Ravallec, Benoit Cudennec, Laurence Guimas, Charles Delannoy, Martine Fouchereau-Peron |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 4, Iss 4, Pp 767-775 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2012.05.004 |
| Popis: |
Siki (Centroscymnus coelolepis) hydrolysates may contain calcitonin gene-related peptide (CGRP)-like molecules. These CGRP-like molecules have attracted attention from the food industry due to their promising applications in the field of functional foods. These CGRP-like molecules were purified and sequenced, and found to show homology to fragments of fish and human collagen. The effect on plasma CGRP-levels of daily gavage with siki hydrolysate containing CGRP-like molecules was further studied in male Wistar rats. The plasma CGRP-levels in rats force fed with the siki hydrolysate were significantly higher than those of the control group. The siki hydrolysate included immunoreactive-CGRP molecules which resisted simulated protein digestion. They were able to cross the intestinal barrier intact and could be responsible for the increase in plasma CGRP levels. This increment in plasma CGRP levels was insufficient to affect body weight or food intake. However, it could lead to other beneficial effects on health. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect