Bone marrow mesenchymal stromal cells in a 3D system produce higher concentration of extracellular vesicles (EVs) with increased complexity and enhanced neuronal growth properties

Autor:	Elmira Jalilian, Hamed Massoumi, Bianca Bigit, Sohil Amin, Eitan A. Katz, Victor H. Guaiquil, Khandaker N. Anwar, Peiman Hematti, Mark I. Rosenblatt, Ali R. Djalilian
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Extracellular vesicles Exosomes Bone marrow mesenchymal stromal cell 3D culture 2D culture Neuronal growth Medicine (General) R5-920 Biochemistry QD415-436
Zdroj:	Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu:	article
ISSN:	1757-6512
DOI:	10.1186/s13287-022-03128-z
Popis:	Highlights Extracellular vesicles (EV) derived from 2D and 3D bone marrow mesenchymal stromal cells (BM-MSCs) demonstrate different characterization phenotype. Heterogeneity and concentration of BM-MSCs-derived extracellular vesicles are highly impacted by the culture conditions. 3D-derived EVs can significantly enhance trigeminal nerves elongation and complexity compared to 2D-derived EVs. 3D culture conditions are highly efficient environment for upscale production of MSC-derived EVs with enhanced neuro-regeneration properties for corneal nerve regeneration.
Databáze:	Directory of Open Access Journals
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