Acute skeletal muscle loss in SARS‐CoV‐2 infection contributes to poor clinical outcomes in COVID‐19 patients

Autor: Amy Attaway, Nicole Welch, Dhweeja Dasarathy, Jocelyn Amaya‐Hughley, Annette Bellar, Michelle Biehl, Siddharth Dugar, Marielle P.K.J. Engelen, Joe Zein, Srinivasan Dasarathy
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 5, Pp 2436-2446 (2022)
Druh dokumentu: article
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.13052
Popis: Abstract Background Chronic disease causes skeletal muscle loss that contributes to morbidity and mortality. There are limited data on the impact of dynamic muscle loss on clinical outcomes in COVID‐19. We hypothesized that acute COVID‐19‐related muscle loss (acute sarcopenia) is associated with adverse outcomes. Methods A retrospective analysis of a prospective clinical registry of COVID‐19 patients was performed in consecutive hospitalized patients with acute COVID‐19 (n = 95) and compared with non‐COVID‐19 controls (n = 19) with two temporally unique CT scans. Pectoralis muscle (PM), erector spinae muscle (ESM) and 30 day standardized per cent change in cross sectional muscle area were quantified. Primary outcomes included mortality and need for intensive care unit (ICU) admission. Multivariate linear and logistic regression were performed. Cox proportional hazard ratios were generated for ICU admission or mortality for the per cent muscle loss standardized to 30 days. Results The COVID‐19 CT scan cohort (n = 95) had an average age of 63.3 ± 14.3 years, comorbidities including COPD (28.4%) and diabetes mellitus (42.1%), and was predominantly Caucasian (64.9%). The proportion of those admitted to the ICU was 54.7%, with 10.5% requiring tracheostomy and overall mortality 16.8%. Median duration between CT scans was 32 days (IQR: 16–63 days). Significant reductions in median per cent loss was noted for PM (−2.64% loss [IQR: −0.28, −5.47] in COVID‐19 vs. −0.06 loss [IQR: −0.01, −0.28] in non‐COVID‐19 CT controls, P
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