| Autor: |
K. Baou, C. Vlachopoulos, I. Dima, N. Ioakeimidis, P. Pietri, D. Terentes-Printzios, D. Kardara, G. Antoniou, C. Stefanadis |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Artery Research, Vol 3, Iss 4 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1876-4401 |
| DOI: |
10.1016/j.artres.2009.10.100 |
| Popis: |
Purpose: Leptin plays a regulatory role in body weight by controlling appetite and energy consumption. Elevated plasma leptin levels (hyperleptinemia) have been suggested to contribute to pathogenesis of diabetes, hypertension, atherosclerosis and coronary heart disease. Arterial stiffness is an independent predictor of cardiovascular risk. We investigated the differential effects of adiponectin, leptin and resistin levels on wave reflections, an index of arterial stiffness in a community population sample. Methods: The study population consisted of 97 subjects (mean age: 46.4±10.5 yrs, 57M/40F), 28 subjects were hypertensives, 22 subjects had dyslipidemia, 4 suffered from diabetes and 32 individuals were obese. Subjects were free of overt cardiovascular disease. Wave reflections were evaluatedwith augmentation index (AIx) of the aortic pressure waveform using commercially available system. Leptin, adiponectin and resistin levels were measured by ELISA kit. Results: Leptin was associated with AIx (r=0.409, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink