Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression

Autor: Ying Jin, Genevieve H. L. Roberts, Tracey M. Ferrara, Songtao Ben, Nanja van Geel, Albert Wolkerstorfer, Khaled Ezzedine, Janet Siebert, Charles P. Neff, Brent E. Palmer, Stephanie A. Santorico, Richard A. Spritz
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-08337-4
Popis: GWAS have led to the identification of 49 genetic loci associated with vitiligo. Here, the authors observe a bimodal distribution of age-of-onset and find a novel genetic locus specifically associated with early-onset vitiligo, located in a regulatory element in the MHC class II region.
Databáze: Directory of Open Access Journals