| Autor: |
Elkahina Ghedir, Abdoullatif Baraket, Souad Kouchar, Selma Rabai, Messaoud Benounis, Albert Alcacer, Angelos Streklas, Joan Bausells, Nadia Zine, Nicole Jaffrezic, Abdelhamid Errachid |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Proceedings, Vol 2, Iss 13, p 1085 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2504-3900 |
| DOI: |
10.3390/proceedings2131085 |
| Popis: |
Monitoring of circulating N-terminal proBNP (NT-proBNP) biomarkers is crucial for the diagnosis of people suffering from heart failure (HF). In this work, we describe a novel ultra-sensitive NT-proBNP immunosensor for NT-proBNP detection in artificial human saliva. The surface of the developed immunosensor based on gold working microelectrodes (WEs) was biofunctionalized through carboxyl diazonium to immobilize anti-NT-proBNP antibodies. The chemical surface modification of WEs was carried out by cyclic voltammetery CV whilst the quantification of NT-proBNP biomarkers was made by electrochemical impedance spectroscopy (EIS). The immunosensor has demonstrated a linear detection response within the range 1–20 pg/mL for NTproBNP detection in artificial human saliva with a good selectivity in the presence of other interferences. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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