Quantitative MRI reveals widespread, network-specific myelination change during generalized epilepsy progression

Autor: Gustavo Chau Loo Kung, Juliet K. Knowles, Ankita Batra, Lijun Ni, Jarrett Rosenberg, Jennifer A. McNab
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: NeuroImage, Vol 280, Iss , Pp 120312- (2023)
Druh dokumentu: article
ISSN: 1095-9572
75564475
DOI: 10.1016/j.neuroimage.2023.120312
Popis: Activity-dependent myelination is a fundamental mode of brain plasticity which significantly influences network function. We recently discovered that absence seizures, which occur in multiple forms of generalized epilepsy, can induce activity-dependent myelination, which in turn promotes further progression of epilepsy. Structural alterations of myelin are likely to be widespread, given that absence seizures arise from an extensive thalamocortical network involving frontoparietal regions of the bilateral hemispheres. However, the temporal course and spatial extent of myelin plasticity is unknown, due to limitations of gold-standard histological methods such as electron microscopy (EM). In this study, we leveraged magnetization transfer and diffusion MRI for estimation of g-ratios across major white matter tracts in a mouse model of generalized epilepsy with progressive absence seizures. EM was performed on the same brains after MRI. After seizure progression, we found increased myelination (decreased g-ratios) throughout the anterior portion (genu-to-body) of the corpus callosum but not in the posterior portion (body-splenium) nor in the fornix or the internal capsule. Curves obtained from averaging g-ratio values at every longitudinal point of the corpus callosum were statistically different with p
Databáze: Directory of Open Access Journals
Externí odkaz: