| Autor: |
Crhistian-Mario Oblitas, Pablo Demelo-Rodríguez, Luis-Antonio Alvarez-Sala-Walther, Manuel Rubio-Rivas, Francisco Navarro-Romero, Vicente Giner Galvañ, Lucía de Jorge-Huerta, Eva Fonseca Aizpuru, Gema María García García, José Luis Beato Pérez, Paula María Pesqueira Fontan, Arturo Artero Mora, Juan Antonio Vargas Núñez, Nuria Ramírez Perea, José Miguel García Bruñén, Emilia Roy Vallejo, Isabel Perales-Fraile, Ricardo Gil Sánchez, José López Castro, Ángel Luis Martínez González, Luis Felipe Díez García, Marina Aroza Espinar, José-Manuel Casas-Rojo, Jesús Millán Núñez-Cortés |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Viruses, Vol 16, Iss 3, p 335 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1999-4915 |
| DOI: |
10.3390/v16030335 |
| Popis: |
Background: This study aimed to validate the role of the D-dimer to lymphocyte ratio (DLR) for mortality prediction in a large national cohort of hospitalized coronavirus disease 2019 (COVID-19) patients. Methods: A retrospective, multicenter, observational study that included hospitalized patients due to SARS-CoV-2 infection in Spain was conducted from March 2020 to March 2022. All biomarkers and laboratory indices analyzed were measured once at admission. Results: A total of 10,575 COVID-19 patients were included in this study. The mean age of participants was 66.9 (±16) years, and 58.6% (6202 patients) of them were male. The overall mortality rate was 16.3% (n = 1726 patients). Intensive care unit admission was needed in 10.5% (n = 1106 patients), non-invasive mechanical ventilation was required in 8.8% (n = 923 patients), and orotracheal intubation was required in 7.5% (789 patients). DLR presented a c-statistic of 0.69 (95% CI, 0.68–0.71) for in-hospital mortality with an optimal cut-off above 1. Multivariate analysis showed an independent association for in-hospital mortality for DLR > 1 (adjusted OR 2.09, 95% CI 1.09–4.04; p = 0.03); in the same way, survival analysis showed a higher mortality risk for DLR > 1 (HR 2.24; 95% CI 2.03–2.47; p < 0.01). Further, no other laboratory indices showed an independent association for mortality in multivariate analysis. Conclusions: This study confirmed the usefulness of DLR as a prognostic biomarker for mortality associated with SARS-CoV-2 infection, being an accessible, cost-effective, and easy-to-use biomarker in daily clinical practice. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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