| Autor: |
Chung-Shan Yu, Ho-Lein Huang, Kuo-Yen Liao, Kun-I Lin, Kee-Ching Jeng, Yi-Hsian Lin, Kai-Shiang Chang, Wen-Chin Su, Yin-Cheng Huang, Li-Wu Chiang |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Molecules, Vol 17, Iss 3, Pp 3058-3081 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules17033058 |
| Popis: |
1-Aminophytosphingosine and 6-aminogalactosyl phytosphingosine were prepared in 61% and 40% yield libraries with 44 carboxylic acids showed that a 4-butylbenzoic acid-derived product exe, respectively. Glycosylation using benzoyl-protected lipid resulted in better a-selectivity for ceramide analogs, but the yield was less than that obtained with benzyl moieties. Screening the amide rted less cytotoxicity. These analogs were purified for validation of immunological potencies and the a-GalCer analog but not the sphingosine analog stimulated human iNKT cell population. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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