Clinical characteristics of chylothorax: results from the International Collaborative Effusion database
| Autor: | José M. Porcel, Silvia Bielsa, Carmen Civit, Avinash Aujayeb, Julius Janssen, Uffe Bodtger, Katrine Fjaellegaard, Jesper Koefod Petersen, Hugh Welch, Jenny Symonds, Michael A. Mitchell, Elżbieta Magdalena Grabczak, Mohamed Ellayeh, Dinesh Addala, John M. Wrightson, Najib M. Rahman, Mohammed Munavvar, Coenraad F.N. Koegelenberg, Gonzalo Labarca, Federico Mei, Nick Maskell, Rahul Bhatnagar |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | ERJ Open Research, Vol 9, Iss 5 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2312-0541 23120541 |
| DOI: | 10.1183/23120541.00091-2023 |
| Popis: | Background Chylothorax is an uncommon medical condition for which limited data are available regarding the contemporary aetiology, management and outcomes. The goal of this study was to better define these poorly characterised features. Methods The medical records of adult patients diagnosed with chylothorax at 12 centres across Europe, America and South Africa from 2009–2021 were retrospectively reviewed. Descriptive and inferential statistics were performed. Results 77 patients (median age 69 years, male to female ratio 1.5) were included. Subacute dyspnoea was the most typical presenting symptom (66%). The commonest cause of chylothorax was malignancy (68.8%), with lymphoma accounting for 62% of these cases. Other aetiologies were trauma (13%), inflammatory/miscellaneous conditions (11.7%) and idiopathic cases (6.5%). At the initial thoracentesis, the pleural fluid appeared milky in 73%, was exudative in 89% and exhibited triglyceride concentrations >100 mg·dL−1 in 88%. Lymphangiography/lymphoscintigraphy were rarely ordered (3%), and demonstration of chylomicrons in pleural fluid was never ascertained. 67% of patients required interventional pleural procedures. Dietary measures were infrequently followed (36%). No patient underwent thoracic duct ligation or embolisation. Morbidity included infections (18%), and thrombosis in malignant aetiologies (16%). The 1-year mortality was 47%. Pleural fluid protein >3.5 mg·dL−1 (sub-distribution hazard ratio (SHR) 4.346) or lactate dehydrogenase |
| Databáze: | Directory of Open Access Journals |
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