Hypoxia and aging

Autor: Eui-Ju Yeo
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Experimental and Molecular Medicine, Vol 51, Iss 6, Pp 1-15 (2019)
Druh dokumentu: article
ISSN: 1226-3613
2092-6413
DOI: 10.1038/s12276-019-0233-3
Popis: Aging: Low oxygen levels promote aging-associated diseases Deficient oxygen supplies to the body’s tissues and a reduced ability to deal with the cellular stress of low oxygen availability both contribute to the ageing process. Eui-Ju Yeo from Gachon University in Incheon, South Korea, reviews the links between insufficient oxygen, a condition known as hypoxia, and the functional decline associated with getting old. Yeo highlights the role that the oxygen-sensing proteins known as hypoxia-inducible factors (HIFs) play in facilitating oxygen supply and regulating energy production under limited oxygen conditions. HIFs also interact with a series of signaling proteins that, when abnormally activated, contribute to many aging-associated diseases. Yeo singles out two hypoxia-related health problems, prenatal hypoxia during early brain development and obstructive sleep apnea, and discusses how they can accelerate aging in various ways.
Databáze: Directory of Open Access Journals
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