Clinical impacts of copy number variations in B-cell differentiation and cell cycle control genes in pediatric B-cell acute lymphoblastic leukemia: a single centre experience

Autor: Crepinsek Klementina, Marinsek Gasper, Kavcic Marko, Prelog Tomaž, Kitanovski Lidija, Jazbec Janez, Debeljak Marusa
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Radiology and Oncology, Vol 56, Iss 1, Pp 92-101 (2021)
Druh dokumentu: article
ISSN: 1581-3207
DOI: 10.2478/raon-2021-0050
Popis: IKZF1 gene deletions have been identified as a poor prognostic factor in pediatric B-cell acute lymphoblastic leukemia (B-ALL), especially in the presence of co-occurring deletions (IKZF1plus profile). This study aimed to determine the frequency of IKZF1 deletions and deletions in other B-cell differentiation and cell cycle control genes, and their prognostic impact in Slovenian pediatric B-ALL patients.
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