In vivo antioxidant efficacy and therapeutic potential of Artemisia brevifolia leaves extract against CCl4-induced reproductive damages in male albino rats

Autor: Muhammad Umar Ijaz, Mudassar Iqbal, Muhammad Adnan Iqbal, Asma Ashraf, K.A. Al-Ghanim, F. Al-Misned, Z. Ahmed, Derya Karataş, Usman Atique, Shahid Mahboob
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of King Saud University: Science, Vol 34, Iss 2, Pp 101816- (2022)
Druh dokumentu: article
ISSN: 1018-3647
DOI: 10.1016/j.jksus.2021.101816
Popis: The current study was aimed to investigate the alleviative effect of Artemisia brevifolia (A. brevifolia) plant extract against CCl4-induced testicular damage in male albino rats. Forty-eight male albino rats were categorized into eight equal experimental groups i.e., control, vehicle control, CCl4 (1 ml/kg), CCl4 + silymarin, CCl4 + A. brevifolia (150 mg/kg), CCl4 + A. brevifolia (300 mg/kg), A. brevifolia (150 mg/kg) and A. brevifolia (300 mg/kg). After 56 days, blood and testicular samples were collected, and antioxidant enzyme activity, lipid peroxidation, hormonal concentration, daily sperm production (DSP), and histomorphometry were analyzed. The animals treated with the A. brevifolia extract exhibited a significant (p
Databáze: Directory of Open Access Journals