| Autor: |
Willy Le Roi Togna Pabo, Aurelie Minelle Kengni Ngueko, Alex Durand Nka, Maria Mercedes Santoro, Yagai Bouba, Collins Ambe Chenwi, Ezéchiel Ngoufack Jagni Semengue, Désiré Takou, Georges Teto, Beatrice Dambaya, Raymond Babila Nyasa, Michel Carlos Tommo Tchouaket, Grace Angong Beloumou, Sandrine Claire Djupsa Ndjeyep, Aude Christelle Ka’e, Tatiana Anim Keng Tekoh, Derrick Tambe Ayuk Ngwese, Naomi-Karell Etame, Rachel Audrey Nayang Mundo, Rachel Simo Kamgaing, Samuel Martin Sosso, Roland Ndip Ndip, Vittorio Colizzi, Francesca Cecchereni-Silberstein, Alexis Ndjolo, Joseph Fokam |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Medicine, Vol 11 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2296-858X |
| DOI: |
10.3389/fmed.2024.1457501 |
| Popis: |
BackgroundThe elevated rate of AIDS-related mortality in Sub-Saharan Africa among adolescents living with HIV (ALHIV) is influenced by various factors, notably immunosuppression, within a framework of limited therapeutic alternatives. We aimed to enhance the management of pediatric HIV by assessing the immune response and associated factors in perinatally-infected ALHIV on antiretroviral therapy (ART) in Cameroon.MethodsA cohort study was conducted from 2018–2020 among 271 ART-experienced ALHIV in Cameroon. Sociodemographic data, immunological (CD4), and virological (plasma viral load, PVL) responses were measured at enrolment (T0), 6-months (T1), and 12-months (T2) using PIMA CD4 (Abbott/Pantech (Pty) Ltd) and Abbott Applied Biosystem platform (Real-Time PCR m2000RT) respectively. Immunological failure (IF) was defined as absolute CD4 |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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