Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors

Autor:	Akira Fukao, Takumi Tomohiro, Toshinobu Fujiwara
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	translation initiation RNA-binding protein microRNA AU-rich element poly(A)-binding protein signaling pathway Cytology QH573-671
Zdroj:	Cells, Vol 10, Iss 7, p 1711 (2021)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells10071711
Popis:	Protein synthesis is tightly regulated at each step of translation. In particular, the formation of the basic cap-binding complex, eukaryotic initiation factor 4F (eIF4F) complex, on the 5′ cap structure of mRNA is positioned as the rate-limiting step, and various cis-elements on mRNA contribute to fine-tune spatiotemporal protein expression. The cis-element on mRNAs is recognized and bound to the trans-acting factors, which enable the regulation of the translation rate or mRNA stability. In this review, we focus on the molecular mechanism of how the assembly of the eIF4F complex is regulated on the cap structure of mRNAs. We also summarize the fine-tuned regulation of translation initiation by various trans-acting factors through cis-elements on mRNAs.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3e861b1759984a8e8555ec5be4ab9b72 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.