| Autor: |
Konstantius R.V. Straat, Marinus J. Hagens, Leonor J. Cools Paulino Pereira, Roderick C.N. van den Bergh, Jan Willem Mazel, M. Arjen Noordzij, Sybren P. Rynja |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
European Urology Open Science, Vol 70, Iss , Pp 52-57 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-1683 |
| DOI: |
10.1016/j.euros.2024.08.017 |
| Popis: |
Background and objective: Current guidelines on prostate cancer (PCa) diagnosis recommend risk stratification before prostate biopsy, using either a risk calculator (RC) or magnetic resonance imaging (MRI). The aim of our study was to assess the effectiveness and cost effectiveness of an RC strategy and a direct MRI (dMRI) strategy. Methods: Data for biopsy-naïve men suspected of having PCa on the basis of elevated prostate specific antigen (PSA) and/or abnormal digital rectal examination (DRE) were retrospectively collected from two large teaching hospitals. The RC and dMRI strategies were evaluated for PCa detection, effectiveness, and costs. The RC strategy used the Rotterdam prostate cancer risk calculator 3/4 and MRI for stratification, while the dMRI strategy directly used MRI findings. Clinically significant (cs)PCa was defined as a Gleason score ≥3 + 4. Key findings and limitations: In total, 1458 men were included for analysis, of whom 944 were in the RC group and 514 were in the dMRI group. The RC strategy significantly reduced MRI use by 47.8% (52.2% vs 99.8%; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
