5-[Substituted]-1, 3, 4-thiadiazol-2-amines: Synthesis, Spectral Characterization, and Evaluation of their DNA interactions
| Autor: | N. Shivakumara, P. Murali Krishna |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Current Chemistry Letters, Vol 8, Iss 3, Pp 157-168 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1927-7296 1927-730X |
| DOI: | 10.5267/j.ccl.2019.4.004 |
| Popis: | The presence of heterocyclic moiety in diverse compounds, strongly indicative of the desired effect on physiological activity, and it reflects on efforts to find useful synthetic drugs. In this connection, here reporting the synthesis and characterization of 5-[substituted]-1, 3, 4-thiadiazol-2-amines (1-7). All the prepared compounds were characterized by spectroscopic viz. 1H-NMR, 13C{1H}-NMR, FT-IR, and LC-MS. The results of the DNA binding interactions using absorption and fluorescence spectroscopy reveal that the compounds are avid binders to DNA. A DNA cleavage study with pUC18 DNA using gel electrophoresis indicates the compounds are able to cleave DNA in presence of oxidant H2O2. |
| Databáze: | Directory of Open Access Journals |
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