Epilepsy in mitochondrial diseases. Clinical lecture

Autor: A. S. Kotov, K. V. Firsov
Jazyk: ruština
Rok vydání: 2023
Předmět:
Zdroj: Русский журнал детской неврологии, Vol 17, Iss 4, Pp 63-70 (2023)
Druh dokumentu: article
ISSN: 2073-8803
2412-9178
DOI: 10.17650/2073-8803-2022-17-4-63-70
Popis: Mitochondrial dysfunction mainly affects organs with high metabolic demand, primarily the brain. Epilepsy is a common phenotypic sign of both syndromic and non-syndromic mitochondrial diseases. Epilepsy in mitochondrial diseases is poorly treatable and is often an unfavorable prognostic sign. Patients with mitochondrial epilepsy are prescribed various anti-seizure medications. Mitochondriotoxic drugs should be avoided. Descriptions of MELAS-syndrome, MERRF-syndrome, Leigh-syndrome, NARP-syndrome are given.
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