Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells

Autor: Alison Taylor, Christopher E. Rudd
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMC Research Notes, Vol 13, Iss 1, Pp 1-7 (2020)
Druh dokumentu: article
ISSN: 1756-0500
DOI: 10.1186/s13104-020-04971-0
Popis: Abstract Objective The threonine/serine kinase glycogen synthase kinase 3 (GSK-3) targets multiple substrates in T-cells, regulating the expression of Tbet and PD-1 on T-cells. However, it has been unclear whether GSK-3 can affect the motility of T-cells and their interactions with antigen presenting cells. Results Here, we show that GSK-3 controls T-cell motility and interactions with other cells. Inhibition of GSK-3, using structurally distinct inhibitors, reduced T-cell motility in terms of distance and displacement. While SB415286 reduced the number of cell-cell contacts, the dwell times of cells that established contacts with other cells did not differ for T-cells treated with SB415286. Further, the increase in cytolytic T-cell (CTL) function in killing tumor targets was not affected by the inhibition of motility. This data shows that the inhibition of GSK-3 has differential effects on T-cell motility and CTL function where the negative effects on cell–cell interactions is overridden by the increased cytolytic potential of CTLs.
Databáze: Directory of Open Access Journals
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