| Autor: |
Tsong‐Hai Lee, Tai‐Ming Ko, Chien‐Hsiun Chen, Ming‐Ta Michael Lee, Yeu‐Jhy Chang, Chien‐Hung Chang, Kuo‐Lun Huang, Ting‐Yu Chang, Jiann‐Der Lee, Ku‐Chou Chang, Jen‐Tsung Yang, Ming‐Shien Wen, Chao‐Yung Wang, Ying‐Ting Chen, Chia‐San Hsieh, Shu‐Yu Chou, Yi‐Min Liu, Hui‐Wen Chen, Hung‐Ting Liao, Chia‐Wen Wang, Shih‐Ping Chen, Liang‐Suei Lu, Yuan‐Tsong Chen, Jer‐Yuarn Wu |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 3 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.115.003003 |
| Popis: |
BackgroundIschemic stroke is a major cause of death and disability in the world. A major ischemic stroke subtype, large‐vessel ischemic stroke (large artery atherosclerosis; LAA), has been shown to have some genetic components in individuals of European ancestry. However, it is not clear whether the genetic predisposition to LAA stroke varies among ethnicities. We sought to identify genetic factors that contribute to LAA stroke in 2 independent samples of Han Chinese individuals. Methods and ResultsNovel genetic variants that predispose individuals to LAA stroke were identified using a genome‐wide association study (GWAS) of 444 individuals with LAA stroke and 1727 controls in a Han Chinese population residing in Taiwan. The study was replicated in an independent Han Chinese population comprising an additional 319 cases and 1802 controls. We identified 5 single‐nucleotide polymorphisms, including rs2415317 (P=3.10×10−8), rs934075 (P=4.00×10−9), rs944289 (P=3.57×10−8), rs2787417 (P=1.76×10−8), and rs1952706 (P=2.92×10−8), at one novel locus on chromosome 14q13.3 within PTCSC3 (encoding papillary thyroid carcinoma susceptibility candidate 3) that were associated with LAA stroke at genome‐wide significance (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text