Amyotrophic lateral sclerosis in a patient who recovered from Miller Fisher Syndrome: The role of GQ1b antibody revisited

Autor: Michael Repajic, Syed Husain, Azadeh Ghassemi, Manvel Kondradzhyan, Antonio Liu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Brain, Behavior, & Immunity - Health, Vol 13, Iss , Pp 100231- (2021)
Druh dokumentu: article
ISSN: 2666-3546
DOI: 10.1016/j.bbih.2021.100231
Popis: Miller Fisher Syndrome (MFS), a variant of Guillain Barre Syndrome (GBS), and amyotrophic lateral sclerosis (ALS) are two rare neuromuscular diseases that are usually unrelated. While ganglioside antibodies have a common relation with MFS and GBS, they have also been found in association, albeit less commonly, with ALS. A patient experiencing MFS and then ALS in tandem has never been documented. We discuss a case demonstrating these findings, with GQ1b elevated on both occasions. The pathophysiologic role of GQ1b is explored.
Databáze: Directory of Open Access Journals