Carnivore chaphamaparvovirus-1 (CaChPV-1) infection in diarrheic dogs reveals viral endotheliotropism in intestine and lung
| Autor: | Chutchai Piewbang, Pattiya Lohavicharn, Tin Van Nguyen, Panitnan Punyathi, Tanit Kasantikul, Somporn Techangamsuwan |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Veterinary Quarterly, Vol 43, Iss 1, Pp 1-10 (2023) |
| Druh dokumentu: | article |
| ISSN: | 01652176 1875-5941 0165-2176 |
| DOI: | 10.1080/01652176.2023.2185696 |
| Popis: | AbstractBackground Carnivore chaphamaparvovirus-1 (CaChPV-1) is a parvovirus identified in dogs and association of infection with diarrhea is controversial. Information on whether tissue tropism persists is lacking.Objectives To determine the disease association of CaChPV-1 in dogs with diarrhea and to investigate viral tropism and genetic diversity.Animals and methods CaChPV-1 infection was investigated in five recently deceased puppies and designed a retrospective study to determine whether the presence of CaChPV-1 is associated with diarrhea. The retrospective study was conducted in 137 intestinal tissue samples and 168 fecal samples obtained from 305 dogs. CaChPV-1 tissue localization was determined using in situ hybridization, and CaChPV-1 complete genomes obtained from dead puppies and retrospective study were sequenced and analyzed.Results CaChPV-1 was detected in 6.56% (20/305) of tested dogs, including 14 diarrheic- and 6 non-diarrheic dogs, and was significant in puppies with diarrhea (p = 0.048). Among the CaChPV-1-positive diarrheic dogs, one sample was obtained from intestinal tissue and 13 samples were fecal samples. However, six CaChPV-1 positive non-diarrheic dogs were based on fecal samples but not on intestinal tissue. Within the age range, the presence of CaChPV-1 was significant in puppies (p |
| Databáze: | Directory of Open Access Journals |
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