Fused Cells between Human-Adipose-Derived Mesenchymal Stem Cells and Monocytes Keep Stemness Properties and Acquire High Mobility

Autor: Karla Montalbán-Hernández, Cesar Casado-Sánchez, José Avendaño-Ortiz, José Carlos Casalvilla-Dueñas, Gloria C. Bonel-Pérez, Julia Prado-Montero, Jaime Valentín-Quiroga, Roberto Lozano-Rodríguez, Verónica Terrón-Arcos, Fátima Ruiz de la Bastida, Laura Córdoba, Fernando Laso-García, Luke Diekhorst, Carlos del Fresno, Eduardo López-Collazo
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Molecular Sciences, Vol 23, Iss 17, p 9672 (2022)
Druh dokumentu: article
ISSN: 1422-0067
1661-6596
DOI: 10.3390/ijms23179672
Popis: Human-adipose-derived mesenchymal stem cells (hADMSCs) are multipotent stem cells which have become of great interest in stem-cell therapy due to their less invasive isolation. However, they have limited migration and short lifespans. Therefore, understanding the mechanisms by which these cells could migrate is of critical importance for regenerative medicine. Methods: Looking for novel alternatives, herein, hADMSCs were isolated from adipose tissue and co-cultured with human monocytes ex vivo. Results: A new fused hybrid entity, a foam hybrid cell (FHC), which was CD90+CD14+, resulted from this co-culture and was observed to have enhanced motility, proliferation, immunomodulation properties, and maintained stemness features. Conclusions: Our study demonstrates the generation of a new hybrid cellular population that could provide migration advantages to MSCs, while at the same time maintaining stemness properties.
Databáze: Directory of Open Access Journals
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