| Autor: |
Hua-Ping Liu, Wei Jia, Gaohaer Kadeerhan, Bo Xue, Wenmin Guo, Lu Niu, Xiaoliang Wang, Xiaolin Wu, Haitao Li, Jun Tian, Dongwen Wang, Hung-Ming Lai |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Translational Oncology, Vol 29, Iss , Pp 101629- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1936-5233 |
| DOI: |
10.1016/j.tranon.2023.101629 |
| Popis: |
TP53 is the most frequently mutated gene in muscle invasive bladder cancer (MIBC) and there are two gene signatures regarding TP53 developed for MIBC prognosis. However, they are limited to immune genes only and unable to be used individually across platforms due to their quantitative manners. We used 827 gene expression profiles from seven MIBC cohorts with varied platforms to build a pairwise TP53-derived transcriptome signature, 13 gene pairs (13-GPs). Since the 13-GPs model is a single sample prognostic predictor, it can be applied individually in practice and is applicable to any gene-expression platforms without specific normalization requirements. Survival difference between high-risk and low-risk patients stratified by the 13-GPs test was statistically significant (HR range: 2.26–2.76, all P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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