Investigation the influence of mechanochemical processing on solubility of verapamil hydrochloride
| Autor: | Stanković Ana V., Jovanović Sonja M. |
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| Jazyk: | English<br />Serbian |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Tehnika, Vol 76, Iss 1, Pp 9-14 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0040-2176 2560-3086 |
| DOI: | 10.5937/tehnika2101009S |
| Popis: | Dissolution of drugs is a very important factor that directly affects their potential application. Due to the fact that solubility may act as a limiting factor in the process of absorption of the drug, it can also affect its bio-availableness. More than 40 percent of potential drugs have a property of a poor solubility in the water, resulting in potentially important pharmaceutical products not reaching patients or reaching their full potential. This work examined the possibility of improving the solubility of verapamil hydrochloride (VHCl) by applying mechanochemical treatment. The impact of mechanochemical treatment on physiochemical properties was comprehended by applying XRPD, FTIR and Raman spectroscopy, as well as FESEM analysis. Besides, particle size distribution was determined. Solubility of verapamil hydrochloride was determined by using UV-VIS spectroscopy. Finally, the solubility of verapamil hydrochloride was correlated with particle size distribution, structural and morphological characteristics. |
| Databáze: | Directory of Open Access Journals |
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