A comparison of antigen-based rapid test and RT-PCR test to diagnose COVID-19 and its infectivity

Autor: Cokorda Agung Wahyu Purnamasidhi, Richard Christian Suteja, I Komang Hotra Adiputra, Giovanca Verentzia Purnama, Ni Kadek Mulyantari, I Ketut Agus Somia
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Romanian Medical Journal, Vol 68, Iss 3, Pp 399-405 (2021)
Druh dokumentu: article
ISSN: 1220-5478
2069-606X
DOI: 10.37897/RMJ.2021.3.11
Popis: Background. Medical screening and diagnostic cost and equipment availability has been a major obstacle to supposed to-be extensive tracing, and overall, to the end of COVID-19 pandemic. Even though RT-PCR is the gold diagnostic standard, it is costly, lengthy, and may be unavailable in remote areas. Therefore, antigen-based COVID-19 rapid tests may be a solution to quickly detect and screen communities suspected of contracting COVID-19. Objective. This paper aims to observe how reliable antigen-based COVID-19 rapid tests are compared to RT-PCR testing. Material and methods. An observational cross-sectional study was performed on 101 samples to find the specificity, sensitivity, and accuracy of antigen-based rapid testing compared to RT-PCR testing performed on every individual. Then, a pattern between CT values and duration between onset of symptoms and testing to antigen-based rapid test result was observed to find a cut-off value such that the person may be deemed safe to exit isolation. Outcomes. A cut-off CT value of above 30.04 (p < 0.01) with a sensitivity of 66.7% and specificity of 77.8% (moderate accuracy) obtained from ROC analysis showed negative results on antigen-based rapid tests. The tests showed an overall accuracy of 67.3%, where results between the two tests were consistent. Conclusion. Therefore, an estimated CT value of 30 was moderately proved to be used as a criterion to end isolation and presume the person no longer sheds SARS-CoV-2.
Databáze: Directory of Open Access Journals
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