Living Kidney Donation in a Type 1 Dent’s Disease Patient from His Mother
| Autor: | Giovanni Gambaro, Alessandro Naticchia, Pietro Manuel Ferraro, Gionata Spagnoletti, Jacopo Romagnoli, Maria Paola Salerno, Franco Citterio |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Kidney & Blood Pressure Research, Vol 44, Iss 5, Pp 1306-1312 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1420-4096 1423-0143 |
| DOI: | 10.1159/000503301 |
| Popis: | Introduction: Dent’s disease is a rare X-linked recessive disorder that manifests in childhood or early adulthood and can lead to end-stage renal disease (ESRD). It occurs in males, who are hemizygous. In patients who develop ESRD, a deceased donor kidney transplant cures the disease. Females are obligate carriers of the mutated gene, and some show a mild Dent’s disease phenotype. There may be reason for concern when considering a female obligate carrier (i.e., the mother) for kidney donation because of the risk of kidney function deterioration. Case Presentation: We describe the first successful kidney transplantation involving a patient with type 1 Dent’s disease and ESRD given a kidney by an obligate carrier of the gene mutation, his mother. Conclusions: After careful assessment of the female obligate carriers, intrafamilial kidney donation in Dent’s disease type 1 is feasible. No deteriorating renal function in the donor was observed. |
| Databáze: | Directory of Open Access Journals |
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