Detection of Trace Amounts of Water in Organic Solvents by DNA-Based Nanomechanical Sensors

Autor: Tomohiro Murata, Kosuke Minami, Tomohiko Yamazaki, Genki Yoshikawa, Katsuhiko Ariga
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Biosensors, Vol 12, Iss 12, p 1103 (2022)
Druh dokumentu: article
ISSN: 2079-6374
DOI: 10.3390/bios12121103
Popis: The detection of trace amounts of water in organic solvents is of great importance in the field of chemistry and in the industry. Karl Fischer titration is known as a classic method and is widely used for detecting trace amounts of water; however, it has some limitations in terms of rapid and direct detection because of its time-consuming sample preparation and specific equipment requirements. Here, we found that a DNA-based nanomechanical sensor exhibits high sensitivity and selectivity to water vapor, leading to the detection and quantification of trace amounts of water in organic solvents as low as 12 ppm in THF, with a ppb level of LoD through their vapors. Since the present method is simple and rapid, it can be an alternative technique to the conventional Karl Fischer titration.
Databáze: Directory of Open Access Journals