Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy?

Autor: Alyaa A. Kotby, Manal M. Abdel Aziz, Waleed M. El Guindy, Amira N. Moneer
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: International Journal of Pediatrics, Vol 2013 (2013)
Druh dokumentu: article
ISSN: 1687-9740
1687-9759
DOI: 10.1155/2013/608563
Popis: Background. Tenascin-C (TN-C) is an extracellular matrix glycoprotein that appears at sites of inflammation in cardiac pathologies. Aim of the Work. To evaluate the role of TN-C as a marker for active inflammation in children with dilated cardiomyopathy (DCM). Subjects and Methods. 24 consecutive patients with primary nonfamilial DCM aged 6–72 months (mean 45.19±11.03) were divided into group I, twelve patients with acute onset DCM (6 months duration), and compared to 20 healthy age- and sex-matched controls. Investigations included estimation of serum TN-C and echocardiographic evaluation using M-mode and 2D speckle tracking echocardiography (STE). Results. Serum TN-C showed a higher significant statistical elevation among patients than controls (P
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