Immunohistochemical Expression of Cytokeratin 19 in Patients with Papillary Thyroid Carcinoma and its Mimics in Erbil, Kurdistan Region, Iraq
| Autor: | Tavga Hushair Dizeyi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Zanco Journal of Medical Sciences, Vol 27, Iss 1, Pp 53-63 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1995-5588 1995-5596 |
| DOI: | 10.15218/zjms.2023.008 |
| Popis: | Background and objective: Papillary thyroid carcinoma (PTC) is the most common primary thyroid cancer. PTC diagnosis is based on the presence of classic nuclear features in most cases. However, there are some mimics including both benign neoplastic and non-neoplastic lesions, therefore immune-histochemical stains are necessary for equivocal cases. This study aimed to evaluate the diagnostic expression of CK19 in different thyroid lesions and also to differentiate PTC from other mimicking thyroid lesions. Methods: A retrospective study of 90 cases of different thyroid lesions (56 patients with benign neoplastic and non-neoplastic lesions and 34 PTC) was investigated from January 2018 to January 2020. Immunohistochemical staining with CK19 was performed. Results: CK19 IHC expressed in about 94% of PTC cases as moderate and strong pattern of staining, while in benign neoplastic and non-neoplastic thyroid lesions only 7% expressed as moderate and non with strong pattern of staining, it showed a significant statistical difference (P |
| Databáze: | Directory of Open Access Journals |
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