Recurrent Atypical Hemolytic Uremic Syndrome: A Masquerade of Antibody-Mediated Rejection?

Autor: Meenakshi Swain, Anisha Manocha, Mudigonda Soma Sekhar
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Indian Journal of Transplantation, Vol 18, Iss 3, Pp 327-329 (2024)
Druh dokumentu: article
ISSN: 2212-0017
2212-0025
DOI: 10.4103/ijot.ijot_24_24
Popis: Atypical hemolytic uremic syndrome (aHUS) is a complement-mediated thrombotic microangiopathy (TMA) resulting from uncontrolled activation of the alternate complement pathway. It is necessary to distinguish a recurrent aHUS posttransplant from de novo aHUS, as the former is usually associated with complement abnormalities and has a poorer prognosis. Furthermore, COVID-19 is believed to unmask underlying complement defects triggering a relapse of aHUS. In this report, we present one such unique histologic presentation of recurrent TMA following a COVID-19 infection, which was not just a diagnostic challenge but could easily have been misdiagnosed as an antibody-mediated rejection.
Databáze: Directory of Open Access Journals