Recurrent Atypical Hemolytic Uremic Syndrome: A Masquerade of Antibody-Mediated Rejection?
| Autor: | Meenakshi Swain, Anisha Manocha, Mudigonda Soma Sekhar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Indian Journal of Transplantation, Vol 18, Iss 3, Pp 327-329 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2212-0017 2212-0025 |
| DOI: | 10.4103/ijot.ijot_24_24 |
| Popis: | Atypical hemolytic uremic syndrome (aHUS) is a complement-mediated thrombotic microangiopathy (TMA) resulting from uncontrolled activation of the alternate complement pathway. It is necessary to distinguish a recurrent aHUS posttransplant from de novo aHUS, as the former is usually associated with complement abnormalities and has a poorer prognosis. Furthermore, COVID-19 is believed to unmask underlying complement defects triggering a relapse of aHUS. In this report, we present one such unique histologic presentation of recurrent TMA following a COVID-19 infection, which was not just a diagnostic challenge but could easily have been misdiagnosed as an antibody-mediated rejection. |
| Databáze: | Directory of Open Access Journals |
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