Biopsy Proven Renal Morphology Cognizance into its Four-Year Evolving Pattern; A Pakistani Perspective

Autor: Zain ul Abedin, Zahid Nabi, Nosheen Anjum, Fasi Hashmi, Khurram Mansoor, Muhammad Ishaque
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Pakistan Armed Forces Medical Journal, Vol 73, Iss 1 (2023)
Druh dokumentu: article
ISSN: 0030-9648
2411-8842
DOI: 10.51253/pafmj.v73i1.8624
Popis: Objective: To determine the pattern of Biopsy Proven Renal Diseases (BPRD) in a single tertiary care centre in Islamabad, Pakistan. Study Design: Cross-sectional study. Place and Duration of Study: Department of Nephrology, KRL Hospital, Islamabad Pakistan, from Mar 2016 to Nov 2020. Methodology: The archival records of all native renal biopsies performed in adults (>18 years) were retrospectively analyzed.The biopsies were performed according to standard indications and evaluated by light microscopy and immunofluorescence. Results: A total of 134 renal biopsies were studied. Among these, 85(61.1 %) were males, and 49(36.5 %) were females. The mean age was 44.70±14.63 years. Primary glomerulonephritis’s were the predominant group of diseases found in 93(69.4%) cases. Membranous nephropathy (MN) was the most common lesion in 52(38.8%), followed by focal segmental Glomerulosclerosis (FSGS) in 22(16.4%) cases. Chronic tubulointerstitial nephritis (Ch. TIN) 12(9.0%) was the third most common lesion among all biopsies. Other diagnoses included lupus nephritis (LN) 10(7.5%) and IgA nephropathy (IgAN) 9(6.7%). One sample one-sided t-test was used to estimate the minimum proportion of occurrence of different biopsies in our concerned population. The estimated minimum proportion of membranous nephropathy (MN) was 0.31, with a p-value of 0.034. Conclusion: We concluded that primary Glomerulonephritis (PGN) is the most common renal disease, and membranous nephropathy is the most common biopsy-proven Glomerulopathy in our concerned population.
Databáze: Directory of Open Access Journals
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