Autor: |
Houari Aissaoui, Morgane Bourne-Watrin, Benoit Lemarie, Genevieve Guillot, Alolia Aboikoni, Piseth Chhorn, Dana Gaudard, Ghazi Hadj-Amara, Ricardo Manasse, Mahamado Ouedraogo, Charles Salloum, Magalie Demar, Loïc Epelboin, Hatem Kallel, Antoine Adenis, Mathieu Nacher, Kinan Drak Alsibai, Dominique Louvel |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
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Zdroj: |
Journal of Fungi, Vol 10, Iss 6, p 400 (2024) |
Druh dokumentu: |
article |
ISSN: |
2309-608X |
DOI: |
10.3390/jof10060400 |
Popis: |
(1) Background: Only a few studies on histoplasmosis in immunocompetent patients have been reported in French Guiana. Therefore, we conducted a detailed clinical description of hospitalized patients suffering with histoplasmosis among non-HIV patients. (2) Methods: This is a single-center, retrospective study conducted at Cayenne Hospital Center between 2008 and 2022. (3) Results: Our cohort was composed of 31 (91%) adults (>18 years of age) and 3 (9%) children, with a sex ratio, M:F, of 1:2. The median age was higher among the women than among the men (70 versus 54 years). The collection of respiratory samples constituted the majority of the performed examinations (38%). Fever (>37 °C) was found in 56% of patients. Surprisingly, the histoplasmosis was disseminated in 82% of patients with an overall case fatality rate of 14.7%. However, immunosuppressive conditions were found in 52% (16/31) of the adult patients, including lymphoid hemopathies, diabetes and immunosuppressive drugs. Conclusions: This disease, though rare and usually considered a mostly benign disease in non-HIV patients, presented a relatively high mortality rate in our cohort. Thus, histoplasmosis should be suspected, screened and investigated as a first line of defense in highly endemic areas, even in immunocompetent and non-HIV patients, especially those with fever or chronic respiratory symptoms. |
Databáze: |
Directory of Open Access Journals |
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