Immunogenicity and Clinical Efficacy Combined Vaccine against Diphtheria, Tetanus and Hepatitis B in Patients with Chronic Obstructive Pulmonary Disease
| Autor: | M. P. Kostinov, N. A. Kulakova, O. O. Magarshak, V. N. Borisova, V. B. Polishchuk, A. M. Kostinova, A. A. Ryzhov, A. M. Kostinov |
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| Jazyk: | ruština |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Эпидемиология и вакцинопрофилактика, Vol 16, Iss 4, Pp 44-51 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2073-3046 2619-0494 |
| DOI: | 10.31631/2073-3046-2017-16-4-44-51 |
| Popis: | The article presents the results of vaccination against diphtheria, tetanus and hepatitis B virus with the use of combined vaccine Bubo-M or a monovalent vaccine Hepatitis B in 120 patients with severe and medium chronic obstructive pulmonary disease (COPD) and 77 healthy people at the age 35 - 60 years. The lack of protective antibodies to diphtheria in patients with COPD was noted. The safety of immunization and the delayed production of post-vaccination antibodies to these infections were shown. The level of post-vaccination antibodies was the same as in healthy group after the administration of 3-rd dose both of the monovaccine and the combined one. During the year a clinical effect in reducing the number of exacerbations of the disease after a triple injection of the combined Bubo-M vaccine in patients with COPD was observed, comparable to that in patients with the combined use of the immunomodulator and hepatitis B vaccine. Moreover combined vaccination with immunomodulator led to normalization of level of the inflammatory mediators. Conclusion: Vaccination of patients with COPD with the use of the combined vaccine Bubo-M has both an advantages in clinical effect and the spectrum of anti-infection protection in comparison with the monovaccine against hepatitis |
| Databáze: | Directory of Open Access Journals |
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