Neuroimagem do transportador de dopamina na doença de Parkinson: primeiro estudo com [99mTc]-TRODAT-1 e SPECT no Brasil Neuroimaging of the dopamine transporter in Parkinson’s disease: first study using [99mTc]-TRODAT-1 and SPECT in Brazil

Autor:	Ming Chi Shih, Edson Amaro Jr, Henrique Ballalai Ferraz, Marcelo Queiroz Hoexter, Fabricio Oliveira Goulart, Jairo Wagner, Li Fu Lin, Ying Kai Fu, Jair Jesus Mari, Acioly Luiz Tavares de Lacerda, Sergio Tufik, Rodrigo Affonseca Bressan
Jazyk:	angličtina
Rok vydání:	2006
Předmět:	dopamina receptor dopaminérgico doença de Parkinson diagnóstico SPECT dopamine transporter Parkinson's disease diagnosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Arquivos de Neuro-Psiquiatria, Vol 64, Iss 3a, Pp 628-634 (2006)
Druh dokumentu:	article
ISSN:	0004-282X 1678-4227
DOI:	10.1590/S0004-282X2006000400021
Popis:	INTRODUÇÃO: Radiotraçadores para neuroimagem de transportador de dopamina (TDA) foram desenvolvidos para estimar a perda de neurônios dopaminérgicos in vivo na doença de Parkinson (DP). OBJETIVO: Avaliar a densidade de TDA in vivo utilizando [99mTc]-TRODAT-1 (INER-Taiwan) e SPECT em uma população de pacientes brasileiros com DP. MÉTODO: Quinze pacientes com DP e 15 controles saudáveis pareados realizaram exames de SPECT com [99mTc]-TRODAT-1 (INER-Taiwan). Estimativas da densidade de TDA estriatal foram calculadas usando potencial de ligação (PL). Pacientes foram avaliados com escalas para PD. RESULTADOS: Pacientes com DP apresentaram redução significativa do PL-TDA (0,38±0,12) comparado aos controles (0,84±0,16, pBACKGROUND: Dopamine transporter (DAT) neuroimaging radiotracers were developed to estimate dopamine neuronal loss in vivo in Parkinson’s disease (PD). OBJECTIVE: To evaluate DAT density in vivo using [99mTc]-TRODAT-1 and single photon computerized tomography (SPECT) in a population of Brazilian PD. METHOD: Fifteen PD patients and 15 matched healthy controls scanned with [99mTc]-TRODAT-1 (INER-Taiwan) and SPECT. Estimates of striatum DAT density were calculated using binding potential (BP). Patients were assessed with PD scales. RESULTS: PD patients had significantly lower striatal DAT-BP (mean±SD) (0.38±0.12) compared to controls (BP=0.84±0.16; p
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