Endogenous testosterone density associates with predictors of tumor upgrading and disease progression in the low through favorable intermediate prostate cancer risk categories: analysis of risk factors and clinical implications

Autor: Antonio B. Porcaro, Alberto Bianchi, Sebastian Gallina, Francesco Ditonno, Paola I. Ornaghi, Emanuele Serafin, Alessandro Tafuri, Andrea Panunzio, Clara Cerrato, Stefano Vidiri, Damiano D’Aietti, Giovanni Mazzucato, Riccardo Rizzetto, Nelia Amigoni, Vincenzo De Marco, Filippo Migliorini, Stefano Zecchini Antoniolli, Matteo Brunelli, Salvatore Siracusano, Maria Angela Cerruto, Alessandro Antonelli
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: African Journal of Urology, Vol 29, Iss 1, Pp 1-13 (2023)
Druh dokumentu: article
ISSN: 1961-9987
DOI: 10.1186/s12301-023-00366-2
Popis: Abstract Background The study aimed to test the hypothesis that endogenous testosterone density (ETD), in the low through favorable intermediate PCa risk classes patients undergoing surgery, might be associated with disease progression. Materials and methods ETD, PSAD, and percentage of biopsy positive cores density (BPCD) were calculated in relation to prostate volume (PV). Tumor load density (TLD) was estimated as the tumor load (TL) ratio to prostate weight. ET was considered low if 2), upstaging (pT > 2) and their related features were investigated. Results 433 patients were included, 249 (57.5%) from the favorable intermediate-risk class. Upgrading occurred in 168 (38.8%) cases and upstaging in 62 (14.3%). ETD above the median (9.9 ng/(dL x mL)), was discriminated by PSAD (AUC = 0.719; 95% CI: 0.671–0.766; p
Databáze: Directory of Open Access Journals
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