Decreased vitamin D levels in children and adolescents with Celiac disease: A nationwide cross-sectional study

Autor: Zülfikar Akelma, Melikşah Keskin, Şenay Savaş Erdeve, Nurbanu Bursa, Osman Çelik, Ersan İmrat, Mustafa Mahir Ülgü, Murat Çağlayan, Naim Ata, Şuayip Birinci
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Gülhane Tıp Dergisi, Vol 64, Iss 3, Pp 268-273 (2022)
Druh dokumentu: article
ISSN: 2146-8052
DOI: 10.4274/gulhane.galenos.2022.38039
Popis: Aims:Vitamin D deficiency results from malabsorption in Celiac disease (CD), and it may also be involved in the pathogenesis of CD. There is no clarity regarding vitamin D deficiency in CD. We investigated the frequency of vitamin D deficiency in children with CD compared with controls.Methods:The database of the Turkish Ministry of Health was used for the cross-sectional descriptive study. Children with CD whose serum tissue transglutaminase (tTG) and serum 25-hydroxyvitamin D [25(OH)D] levels were available in the registry were included. The CD group was further subdivided into tTG (IgG and/or IgA) antibody-negative and positive subgroups. Individuals with CD were classified as compatible and non-compatible with a gluten-free diet (GFD) (GFD-compatible and GFD-non-compatible groups), respectively. Children who had no known malabsorption syndrome formed the control group.Results:The median serum 25(OH)D level was 18.5 ng/mL in children with CD (n=6717) and 30.7 ng/mL in the control group (n=6717) (p
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